Opportunity Information: Apply for PAS 19 391
The National Institutes of Health (NIH), within the U.S. Department of Health and Human Services, announced a discretionary grant opportunity titled "Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Archiving and Leveraging Existing Data Sets for Analyses (R03 Clinical Trial Not Allowed)." The opportunity number is PAS-19-391, and it falls under the health funding activity category (CFDA 93.866). It uses the NIH R03 mechanism, which is designed for small, focused research projects, and it explicitly does not allow clinical trials, meaning applicants must propose work that analyzes existing information rather than testing interventions in humans through a trial design.
The program is intended to support innovative, high-value projects that can generate scientific insights to improve prevention, diagnosis, treatment, and care for people affected by Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). The specific emphasis is on archiving and leveraging existing data sets for analysis, so the strongest applications are likely to center on reusing, combining, curating, harmonizing, or otherwise extracting new knowledge from data that already exist. This can include many types of research-relevant resources, such as previously collected clinical data, epidemiologic cohorts, neuroimaging archives, genomics or other omics data, digital health data, neuropathology data, or well-characterized observational study data, as long as the proposed approach is analytic and not a clinical trial.
A major goal of the funding announcement is workforce development and field expansion. First, it aims to encourage the next generation of U.S. researchers to build research and academic careers in neuroscience, AD/ADRD, and healthy brain aging by providing a manageable entry point to conduct a publishable, career-building project. Second, it aims to attract established researchers who are not currently focused on AD/ADRD by supporting pilot studies that allow them to apply their existing expertise to Alzheimer’s and related dementias. In practice, this means proposals that adapt methods from adjacent disciplines (for example, advanced statistics, machine learning, bioinformatics, health services research, behavioral science, or computational neuroscience) to AD/ADRD questions are a strong thematic fit, particularly when the work uses existing datasets to quickly produce new findings or generate preliminary evidence that can support later, larger grant applications.
The announcement also highlights NIH’s interest in broadening participation. Individuals from underrepresented racial and ethnic groups, as well as individuals with disabilities, are specifically encouraged to apply for NIH support. While this does not change the scientific requirements, it signals that the program values inclusive participation in the AD/ADRD research workforce and is aligned with NIH-wide efforts to strengthen diversity in biomedical research.
In terms of basic funding parameters, the award ceiling listed is $100,000, and NIH anticipated making about 12 awards. The opportunity was created on October 7, 2019, and the original closing date was November 16, 2022. Eligible applicants are broad and include many types of U.S. organizations: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and other entities as allowed by NIH’s additional eligibility language. Overall, this is a relatively accessible NIH mechanism for institutions that can support a concise project using existing AD/ADRD-related data, with a clear expectation that the work will be impactful, analytically rigorous, and positioned to seed future, larger-scale research in Alzheimer’s and related dementias.Apply for PAS 19 391
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Small Research Grant Program for the Next Generation of Clinical Researchers in AD/ADRD Research: Area of Focus Archiving and Leveraging Existing Data Sets for Analyses (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Oct 07, 2019.
- Applicants must submit their applications by Nov 16, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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