Opportunity Information: Apply for PAR 25 219
The Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies (R33 Clinical Trial Optional) funding opportunity (PAR-25-219) is an NIH grant program designed to support the development of new or significantly improved research infrastructure that can push aging science forward in areas where progress depends on interdisciplinary collaboration. The emphasis is not simply on funding another individual research project, but on building or advancing shared capabilities, platforms, tools, resources, networks, or other infrastructure that multiple investigators or disciplines can use to answer important questions in aging. The intent is to strengthen the field by enabling partnerships across different scientific domains, which is often necessary in aging research where biological, clinical, behavioral, social, and environmental factors intersect.
This opportunity uses the R33 activity code, which generally aligns with later-stage development or advanced implementation rather than early feasibility work. In practical terms, applicants are expected to propose infrastructure that is ready to be developed, integrated, scaled, or deployed in a way that will have a clear impact on aging research. The "Clinical Trial Optional" designation means applicants may include a clinical trial if it is appropriate for the infrastructure being proposed, but a clinical trial is not required. The infrastructure itself should be central to the application, with a credible plan showing how it will be built, validated, and utilized by the intended research community or collaborative group.
Eligibility is broad and covers a wide range of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education and private institutions of higher education. Tribal entities are eligible, including federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized. The NOFO also allows nonprofits with or without 501(c)(3) status (as long as they are not higher education institutions), public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), and small businesses. In addition, the announcement explicitly highlights several institution types and community-rooted organizations as eligible, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), along with faith-based or community-based organizations, regional organizations, and eligible federal government agencies. U.S. territories or possessions are also listed as eligible applicants.
At the same time, there are clear restrictions related to non-U.S. applicants and components. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the primary applicant organization, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" as defined by the NIH Grants Policy Statement are allowed, meaning a U.S. applicant can include certain types of international collaboration or work performed outside the United States if it meets NIH policy requirements and is appropriately justified and documented. This setup allows applicants to draw on unique expertise or resources internationally while keeping the primary awardee and main organizational responsibility within an eligible U.S. entity.
Administratively, this is an NIH discretionary grant opportunity within the health funding activity category, associated with CFDA numbers 93.313 and 93.866. The posted original application due date is December 2, 2025. The opportunity listing does not provide an award ceiling or the expected number of awards in the supplied text, so applicants would need to consult the full NOFO for budget guidance, project period expectations, review criteria, and any institute- or program-specific priorities tied to aging research infrastructure.
Overall, the core message of PAR-25-219 is that NIH is looking to invest in durable, reusable, interdisciplinary infrastructure that meaningfully expands what aging researchers can do, especially in areas where progress is bottlenecked by a lack of shared resources, coordinated partnerships, or specialized platforms. Applicants are expected to demonstrate both strong technical plans for development and a credible strategy for real-world utilization by a broader community of aging researchers, not just by a single lab or narrow team.Apply for PAR 25 219
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies (R33 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.866.
- This funding opportunity was created on 2024-11-07.
- Applicants must submit their applications by 2025-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
1. What is PAR-25-219?
PAR-25-219 is an NIH funding opportunity titled "Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies (R33 Clinical Trial Optional)." It supports advanced-stage development and use of research infrastructure intended to move aging science forward through interdisciplinary collaboration.
2. What is the main goal of this funding opportunity?
The main goal is to build, advance, scale, integrate, or deploy shared research infrastructure that multiple investigators or disciplines can use to address important questions in aging. The emphasis is on durable, reusable capabilities that strengthen the broader aging research field, rather than supporting a single standalone research project.
3. What does NIH mean by "research infrastructure" in this program?
Based on the description provided, "research infrastructure" can include shared capabilities, platforms, tools, resources, networks, or other infrastructure elements that enable multiple investigators and disciplines to conduct or accelerate interdisciplinary aging research.
4. Is this opportunity intended to fund individual research projects?
No. The opportunity explicitly emphasizes that it is not simply funding another individual research project. The infrastructure itself should be central, with a plan for development, validation, and utilization by a broader community or collaborative group.
5. What does the R33 activity code indicate for this opportunity?
This opportunity uses the NIH R33 activity code, which generally aligns with later-stage development or advanced implementation rather than early feasibility work. Applicants are expected to propose infrastructure that is ready for advanced development, integration, scaling, or deployment with a clear impact on aging research.
6. What does "Clinical Trial Optional" mean?
"Clinical Trial Optional" means applicants may include a clinical trial if it makes sense for the proposed infrastructure, but a clinical trial is not required. The central focus must remain on the infrastructure and its value to the aging research community.
7. Who is eligible to apply?
Eligibility is broad and includes a wide range of U.S.-based organizations and governmental entities. Examples listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; and private institutions of higher education.
8. Are tribal entities eligible?
Yes. The opportunity states that tribal entities are eligible, including federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized.
9. Are nonprofits eligible to apply?
Yes. The NOFO allows nonprofits with or without 501(c)(3) status, as long as they are not higher education institutions (as described in the provided information).
10. Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
11. Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included in the listed eligible applicant types.
12. Are community-based and faith-based organizations eligible?
Yes. The announcement explicitly highlights faith-based or community-based organizations as eligible (among other types of community-rooted or regional organizations).
13. Are minority-serving institutions specifically mentioned as eligible?
Yes. The eligibility description explicitly highlights institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
14. Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible applicants.
15. Can a non-U.S. (foreign) organization apply as the primary applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the primary applicant organization.
16. Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply, according to the restrictions described.
17. Are any types of international collaboration allowed?
Yes. The information provided states that "foreign components" (as defined by the NIH Grants Policy Statement) are allowed. This means a U.S. applicant may include certain types of international collaboration or work performed outside the United States if it meets NIH policy requirements and is justified and documented appropriately.
18. What kinds of scientific areas does this infrastructure support?
The opportunity is aimed at interdisciplinary aging studies, recognizing that aging research often involves intersecting biological, clinical, behavioral, social, and environmental factors. The infrastructure is intended to enable partnerships across different scientific domains.
19. What is NIH looking for in a strong application concept?
Based on the provided description, NIH is looking for infrastructure that is central to the proposal and accompanied by a credible plan to build it, validate it, and ensure it is utilized by an intended research community or collaborative group, not just a single lab or narrow team.
20. What is the application due date?
The posted original application due date provided is December 2, 2025.
21. What funding category is this opportunity associated with?
This is described as an NIH discretionary grant opportunity within the health funding activity category.
22. What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.313 and 93.866.
23. Is there an award ceiling listed in the provided information?
No. The supplied text states that the opportunity listing does not provide an award ceiling.
24. Does the provided information specify the expected number of awards?
No. The supplied text states that the expected number of awards is not provided in the information shown.
25. Where should applicants look for budget guidance and other details not included here?
The provided description indicates applicants would need to consult the full NOFO for budget guidance, project period expectations, review criteria, and any institute- or program-specific priorities tied to aging research infrastructure.
26. What is the overall message or priority of PAR-25-219?
The core message is that NIH aims to invest in durable, reusable, interdisciplinary infrastructure that expands what aging researchers can do, especially where progress is limited by missing shared resources, coordinated partnerships, or specialized platforms.
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