Opportunity Information: Apply for RFA HG 20 002
The Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Coordinating Center opportunity (Funding Opportunity Number RFA HG 20 002) is a National Institutes of Health cooperative agreement (U01; clinical trial not allowed) that focuses on building the central hub for a larger research Consortium aimed at improving polygenic risk scores for people from diverse ancestral backgrounds. The core idea behind the program is that most existing PRS models have been developed primarily using datasets dominated by individuals of European ancestry, which can reduce accuracy and usefulness when those same models are applied to other populations. This grant supports a Coordinating Center (CC) that will provide the shared backbone for multi-site work to generate, refine, evaluate, and disseminate PRS methods and results that perform better across a wide range of ancestries and health outcomes.
Functionally, the Coordinating Center is meant to serve as the Consortium's organizing and technical engine. Rather than being one more disease-focused research site, the CC is expected to deliver centralized support, infrastructure, coordination, and analytic capacity that enables multiple PRS Centers (funded under a separate funding announcement) to work together efficiently. The CC's role includes facilitating collaboration across grantees, supporting harmonization and integration of large-scale genomic and phenotype datasets, and enabling consistent analytic pipelines and shared practices across the Consortium. In practical terms, that implies building or operating shared computational and data-management systems, establishing common data standards and workflows, helping align phenotype definitions and covariates across studies, and coordinating the movement or federated analysis of data in ways that respect consent, privacy, and governance requirements.
The scientific and programmatic objectives are organized around two main goals. First, the Consortium is expected to leverage genetic diversity to develop improved PRS methods and to increase the applicability of PRS for predicting health and disease risk across diverse populations. This is not limited to a single condition; the program explicitly targets a broad range of complex diseases and traits, meaning the methods and resources should generalize across multiple phenotypes and reflect real-world complexity. Second, the Consortium aims to optimize how large-scale, harmonized genomic and phenotype data are integrated so that collaborative analysis becomes easier and more reliable. That includes creating processes and tools that make it possible to compare methods fairly across datasets, evaluate portability across ancestries, and support transparent dissemination of PRS-related outputs and method improvements.
Because this is a cooperative agreement, the NIH is expected to have substantial involvement in the project, and the Coordinating Center is positioned as a key mechanism for ensuring that the overall Consortium functions as a coordinated program rather than a collection of independent projects. The award mechanism signals an emphasis on shared milestones, coordinated decision-making, and ongoing partnership among the awardee, NIH program staff, and the PRS Centers. The listing also indicates that only one award is expected for the Coordinating Center, reinforcing that the CC is intended to be a single, central node providing services to the entire Consortium.
From an eligibility standpoint, the opportunity is broadly open to many organization types, including state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities as described in the additional eligibility language. The sponsoring agency is the U.S. Department of Health and Human Services through the NIH, and it is categorized under health research (CFDA 93.172). The opportunity was created March 23, 2020, with an original closing date of June 23, 2020. The published award ceiling is listed as 0, which typically indicates that the ceiling is not specified in that summary field rather than implying no funding; applicants would normally confirm budget expectations and limits in the full announcement.
Overall, this funding announcement is best understood as an infrastructure-and-coordination award designed to make large-scale, multi-institution PRS research feasible and consistent, with a clear emphasis on equity and scientific validity across ancestries. The Coordinating Center is expected to help the Consortium move from fragmented, ancestry-limited PRS development toward more generalizable methods, better harmonized data resources, and more widely usable PRS outputs that can support future research and, eventually, more equitable risk prediction in diverse populations.Apply for RFA HG 20 002
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry Coordinating Center (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on Mar 23, 2020.
- Applicants must submit their applications by Jun 23, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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